MINNEAPOLIS – Sixty yards in 16 seconds? No problem.

On third-and-6 and with time not on Minnesota's side, Kirk Cousins fired across the middle to Jordan Addison, who not only made the catch but maintained possession when Charvarius Ward also got a grip on the ball.

Addison ripped the pigskin from the cornerback's hands and was off to the races, sprinting all the way to the end zone for a 60-yard touchdown.

The rookie receiver showed up and showed out under the lights of Monday Night Football, helping Minnesota upset San Francisco 22-17 at U.S. Bank Stadium.

"Every time the ball came my way, I'm just making sure I'm making a play for Kirk," Addison said.

Cousins described the long touchdown, pointing out the 49ers Cover 0 blitz on the play.

"[They] were kind of zeroed out on the back end and I had to throw it earlier than I wanted to, and I didn't really know where to lead him. I was like, 'I don't want to over-lead him,' and then what I did was I under-led him, so you allow the DB to undercut it," Cousins said. "I thought it was getting picked, and Jordan, I still don't know. I haven't seen it yet in slow motion, so I don't know how Jordan came away with it, and because they were zeroed out, once he pulls away, there's nobody left. Big-, big-time play by him."

Addison's splash play felt even sweeter after Ward had taken the ball from Addison earlier in the night, turning the Vikings third overall play into an interception.

"After that play I was just thinking, 'I've gotta kill it the rest of the game,' " he said.

So when a similar situation presented itself, Addison wasn't letting go.

"You ain't gonna get it twice. No sir," he said. "I needed that one."

The rookie played a huge role in the Vikings win, the second game since Justin Jefferson landed on Injured Reserve.

Vikings coaches and players alike have emphasized confidence in teammates' ability to step up in Jefferson's absence, and they certainly did so in an electric atmosphere and on national television.

"[We made a] statement that we're serious," running back Cam Akers said. "That we are who we say we are. And that we're here. We're playing football.

"On a national scale, Monday Night Football, everybody watching – what better time than to go out and put it all together on full display?" he added. "We played a complete game. We want to keep stacking the blocks."

Akers noted that prior to Monday's game, he told Addison, "I'm gonna need two [touchdowns] outta you tonight."

Addison delivered, racking up a career-high 123 receiving yards and a pair of touchdowns. The 60-yarder was his second on the evening, his first being a 20-yard pass from Cousins 10 minutes into the game.

"I had a linebacker on me, and as soon as I turned around, the ball was there," Addison said. "I just gave him late hands. A linebacker covering me, that's like a fish out of water. He doesn't really know what's going on."

Addison joined Jefferson and Hall of Famer Randy Moss as Vikings rookies to post 100 or more receiving yards on Monday Night Football.

He has just seven pro games under his belt, but Addison's already showing he's the real deal.

"I told him after the game, 'Your play before the half won the game, and there's probably two more plays out there that we can connect on for touchdowns, too," Cousins said. "It's exciting to see his potential and the playmaker he is, and there's a lot of things about his ability that you can't teach and we're fortunate to have."

Addison shined bright, but he wasn't the only one. It was all-hands-on-deck by Minnesota's offense to get the job done against San Francisco.

Cousins finished his outing 35-of-45 passing for 378 yards, two touchdowns and one interception with a passer rating of 107.2. He spread the ball around, giving touches to 12 different players.

"We know we've got a special room of skill guys," left tackle Christian Darrisaw said. "We know if we just give Kirk the time, those dudes are gonna get open, Kirk's gonna find them and big things are going to happen."

T.J. Hockenson had a big performance, fittingly the day after National Tight Ends Day, with 11 catches for 86 yards. Brandon Powell added five catches for 47 yards, K.J. Osborn had five catches for 47 yards and Akers had two receptions for 30 yards.

Trishton Jackson was elevated from the practice squad for Monday's game and nabbed his first career reception, a 7-yard grab that set up Greg Joseph for a 54-yard field goal late in the third quarter.

"I didn't even realize until I got to the sideline and everyone was dapping me up, and I was like, 'What're you all dappin' me up for?' They had to tell me," laughed Jackson, who did log catches in the Vikings preseason games. "It was fun. It was cool. I told our equipment staff, 'I need that ball.' "

Jackson reminded even though Jefferson is sidelined, he continues to lead from that sideline – and he's proud of the wideout group.

"Everyone was worried [on the outside] was worried, but me, [receivers coach Keenan] McCardell, Justin – everyone in our room really says … 'We've just gotta go out there and play,' " Jackson said. "We want to marry the run and the pass, go out there and block and just have fun."

On the ground, Akers had 31 yards on 10 carries, while Alexander Mattison recorded eight carries for 39 yards.

Minnesota's offensive line took care of business all four quarters, not allowing a single sack of Cousins by a talented Niners front. The 49ers had recorded at least one sack in every other game this season.

"They knew the challenge. Listen, Nick Bosa is a phenomenal, phenomenal player, and you have to be locked in on every single snap all night long, regardless of circumstance," O'Connell said. "But they also have [Arik] Armstead and [Javon] Hargrave, and they have other players that continuously come at you. If you're not locked in for one moment, it can be catastrophically bad.

"Tackles have been really, really good all year for us, but to answer the bell like they did tonight, can't say enough about C.D. (Darrisaw) and Brian O'Neill for what they mean to this team," O'Connell added.

He also complimented Dalton Risner, who started in place of an injured Ezra Cleveland.

Risner was all smiles following the win.

"We were pass-blocking our butts off. I've never pass-blocked like that and just kept looking up and seeing balls completed, and touchdowns, and throws," he said. "I was like, 'I can get used to this, man. This is awesome.' Just so many playmakers."

Minnesota improved to 3-4 after the win, with back-to-back road games at Green Bay and Atlanta next on the docket.

The Vikings know they have to continue to dig themselves out of a hole, but they feel good about the locker room and talent to do it.

"There's just something different about this place. It starts with the top down, and O'Connell, and the way this team is ran. And the locker room, and how we block out the noise, and how we go to work at practice. This team knows how to celebrate, too," said Risner, who spent his first four seasons in Denver. "I just know we're not a 2-4 football team, and we went out and proved that tonight against one of the better, top-five teams in the NFL."

With back-to-back wins against the Bears and now the Niners, the Vikings message is clear: Keep your head down, and just keep stacking.

"This is real big," Addison said. "It's a 17-game season. Let's go 1-0 next week. Let's just keep going 1-0. It felt good to get our first win at home tonight."