For the second straight week, the Vikings trailed at halftime due to a poor performance in the opening 30 minutes.
And for the second straight week, it was too much to overcome as Minnesota fell 28-11 on the road to Indianapolis.
The Vikings are now 0-2 to start the season for the first time under Vikings Head Coach Mike Zimmer.
Minnesota was outgained 199 to 97 in the opening half, with 75 of those yards for the Vikings coming on their first drive. It ended with a 21-yard field goal from Dan Bailey.
The Vikings also held the ball for just 12:21 in the opening half, compared to 17:39 for the Colts.
Nearly six minutes of that time of possession came on Minnesota's first drive, while the other six-plus minutes was spread out over five possessions.
Through two games, the Vikings have been outscored 37-13 in opening halves.
View game action images as the Vikings take on the Colts at Lucas Oil Stadium.
Here are four more takeaways from Sunday:
1. A big day for Wilson
Eric Wilson provided a bright spot for the Vikings defense as he recorded the first interception of his NFL career.
With the Colts in the red zone, Harrison Smith broke up a Philip Rivers pass, and the ball bounced right into Wilson's hands.
He was tackled for no gain, but the former undrafted free agent was mobbed by his teammates in celebration.
Wilson also made another notable play early in the third quarter when he perfectly read a pass in the flat and made the tackle for a 7-yard loss.
2. Yet another safety
Over the course of an NFL season, you're bound to see a safety here and there.
The Vikings have now seen two safeties in back-to-back weeks, and have been on the wrong end of each one.
Kirk Cousins was sacked in the end zone yet again Sunday, as the play gave the Colts a 9-3 lead with less than five minutes left in the second quarter.
Cousins appeared to maneuver his way out of the end zone, but officials ruled the play day and awarded the safety to Indianapolis.
Cousins was also sacked for a second-quarter safety against Green Bay in Week 1.
Going back to Week 17 of 2019, the Vikings have allowed a safety in three consecutive regular-season games.
3. Costly offensive penalties
Vikings tight end Irv Smith, Jr., was on the wrong end of a pair of penalties that hampered the Vikings offense against the Colts.
Down 7-3 early in the second quarter, the Vikings faced a third-and-9 at their own 21-yard line.
Kirk Cousins hit Smith for 10 yards and a first down, but the tight end was called for offensive pass interference that negated the play. The Vikings ran the ball on third-and-19 and then punted.
In the third quarter, the Vikings trailed 18-3 and were in need of a spark. Minnesota had moved the ball to the Colts 40 and was looking to get into scoring range.
But Smith was called for an illegal crackback block — a 15-yard penalty — that forced the Vikings into a first-and-25 situation from their own 45. And after a short Dalvin Cook run and a sack on Cousins, it was third-and-27 from the Vikings 43.
The Vikings then punted, but were called for illegal touching on the play, forcing Britton Colquitt to punt again when it was now fourth-and-32 at their own 38.
All in all, instead of looking to get into scoring range, the Vikings ended up punting from their own territory.
4. Ngakoue continues success vs. Colts
Yannick Ngakoue recorded his first sack as a Viking on Sunday, and continued his recent run of success against the Colts.
Ngakoue got to Rivers early in the third quarter and forced a fumble on the play, but the ball was recovered by the Colts.
In nine career games against Indianapolis, Ngakoue now has 7.5 career sacks and has recorded at least one sack in six separate games. He's also forced four fumbles.
Ngakoue's sack was the lone one of Rivers on Sunday.